Hypoxia-inducible factors: a central link between inflammation and cancer
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چکیده
منابع مشابه
Hypoxia - inducible factors : a central link between inflammation and cancer
Introduction The tumor microenvironment is similar to an inflammatory focus, as it consists of a complex milieu of both innate and adaptive immune cells (1). Hypoxia is a characteristic feature of both tumors and inflammatory foci. Increased metabolic demand from rapid cell turnover, immune cell infiltration, and vascular disruption cause local O2 tension to decline. The decreased O2 tension of...
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The tumor immune response is in a dynamic balance between antitumor mechanisms, which serve to decrease cancer growth, and the protumor inflammatory response, which increases immune tolerance, cell survival, and proliferation. Hypoxia and expression of HIF-1α and HIF-2α are characteristic features of all solid tumors. HIF signaling serves as a major adaptive mechanism in tumor growth in a hypox...
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Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specif...
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Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts significant influence on their progression. Macrophages and neutrophils are major cellular components of innate immunity and contribute not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation....
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In the last decade a growing body of epidemiological and clinical data has emerged to support the concept that longstanding inflammation potentiates or promotes tumor development, growth and progression. Among pro-inflammatory gene products involved in such interactions are tumor necrosis factor (TNF)-·, interleukin (IL)-6 and vascular endothelial growth factors (VEGFs), whose expression is mai...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci84430